Date | Opponents | | Score | Scorers | Crowd |
PRE-SEASON FRIENDLIES |
| 10/7/10 | Curzon Ashton | H | 2 - 2 | Jones, Trennery | 161 |
| 17/7/10 | Whitley Bay | A | 0 - 1 | | 417 |
| 21/7/10 | FC United Of Manchester | H | 0 - 0 | | 340 |
| 28/7/10 | Chapel Town (High Peak Cup Semi-Final) | H | 4 - 1 | Elliot, Kharas, Oakes, Kay (pen) | 202 |
| 31/7/10 | Stockport County | H | 0 - 3 | | 458 |
| 4/8/10 | Buxton (High Peak Cup Final) | A | 0 - 5 | | 254 |
LEAGUE & CUP MATCHES |
| 7/8/10 | Padiham | A | 0 - 3 | | 122 |
| 11/8/10 | Flixton | H | 5 - 1 | Kay (2, 1 pen), Kharas(2), Elliot | 222 |
| 14/8/10 | Wigan Robin Park (FA Cup) | H | 2 - 2 | Butorins, Trennery | 223 |
| 17/8/10 | Wigan Robin Park (FA Cup Replay) | A | 1 - 0 | Jones | 115 |
| 21/8/10 | Rossendale United | A | 0 - 2 | | 102 |
| 25/8/10 | Stone Dominoes | H | 2 - 2 | Trucca(2) | 135 |
| 28/8/10 | St Helens Town (FA Cup) | A | 1 - 1 | Morris (pen) | 113 |
| 1/9/10 | St Helens Town (FA Cup Replay) | H | 3 - 1 | Barker, Elliot, Oakes (pen) | 229 |
| 4/9/10 | Squires Gate | H | | | |
| 7/9/10 | Maine Road | A | | | |
| 11/9/10 | Mossley (FA Cup 1st Qualifying Round) | H | | | |
| 14/9/10 | Congleton Town | A | | | |
| 18/9/10 | Blackstones / Shirebrook Town (FA Vase) | A | | | |
| 25/9/10 | St Helens Town | H | | | |
| 2/10/10 | (FA Vase Date) | | | | |
| 9/10/10 | Ramsbottom United | H | | | |
| 16/10/10 | Winsford United | A | | | |
| 19/10/10 | Radcliffe Borough (Manchester Premier Cup) | H | | | |
| 23/10/10 | Bacup Borough | H | | | |
| 27/10/10 | Runcorn Linnets | H | | | |
| 30/10/10 | St Helens Town | A | | | |
| 6/11/10 | Colne (League Cup) | H | | | |
| 13/11/10 | Stone Dominoes | A | | | |
| 17/11/10 | Atherton LR | H | | | |
| 20/11/10 | Formby | A | | | |
| 27/11/10 | Colne | H | | | |
| 4/12/10 | Bacup Borough | A | | | |
| 11/12/10 | Padiham | H | | | |
| 18/12/10 | Bootle | A | | | |
| 27/12/10 | New Mills | H | | | |
| 3/1/11 | Flixton | A | | | |
| 8/1/11 | Formby | H | | | |
| 15/1/11 | Colne | A | | | |
| 22/1/11 | Congleton Town | H | | | |
| 5/2/11 | Ramsbottom United | A | | | |
| 12/2/11 | Alsager Town | A | | | |
| 19/2/11 | Barnoldswick Town | H | | | |
| 26/2/11 | Maine Road | H | | | |
| 5/3/11 | Silsden | H | | | |
| 12/3/11 | Runcorn Linnets | A | | | |
| 19/3/11 | Barnoldswick Town | A | | | |
| 26/3/11 | Silsden | A | | | |
| 2/4/11 | Bootle | H | | | |
| 9/4/11 | Rossendale United | H | | | |
| 16/4/11 | Ashton Athletic | A | | | |
| 23/4/11 | Winsford United | H | | | |
| 25/4/11 | New Mills | A | | | |
| 30/4/11 | Squires Gate | A | | | |
| TBA | Alsager Town | H | | | |
| TBA | Atherton LR | A | | | |
| TBA | Ashton Athletic | H | | | |
